Remarkably, the kinetics of shuttling was different among the two cell lines, with a more prolonged time of nucleolar APE1 emptying in HCC1937 cells compared to HCC70 cells, probably due to their different response to CDDP and CBDCA treatments Additional file 2 Figure S1 and Additional file 3 Figure S2 [Only registered and activated users can see links. Click Here To Register...] Tissue embedding, processing, and immunohistochemistry