Apart from the IgE mediated allergic reactions which can be induced by protein allergens, bivalent molecules, monovalent allergens true haptens presented to basophils by a carrier macromolecule, anti IgE antibodies, anti FcОµRI receptor antibodies, etc, so called non IgE mediated reactions do also exist or are related to allergens for which an IgE mechanism has not been clearly established

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