Thus the objectives of this study were to examine 1 the specificity and potency of E 2 compared with other steroid hormones on the follicle cycle, 2 the potency of ICI 182780 compared with other ER antagonists, 3 whether ER О± and or ER ОІ is expressed in mouse skin, and 4 whether the effects of topically applied E 2 and ICI 182780 on the regulation of the hair follicle cycle are due to their local effects within the skin or to a secondary systemic effect resulting from their cutaneous absorption

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