Thirty six patients 19 with MGUS and 17 with SMM were randomly assigned to receive either 4, 000 mg of the curcumin containing product curcumin stick pack contained 3, 600 mg of curcumin, 320 mg of demethoxycurcumin, and 80 mg of bisdemethoxycurcumin; one half in the morning and one half in the evening as a divided dose or 4, 000 mg of placebo, crossing over at 3 months

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