To investigate the anti proliferative effects of the combination of berberine and evodiamine, MCF 7 cells were treated with or without the indicated concentrations of berberine, evodiamine, or their combination for 48 h [Only registered and activated users can see links. Click Here To Register...] I think Tamoxifen can take quite a while to clear out of our systems, and that is why the spotting kept up for a few months