5 times the human 5 mg intravenous dose, based on body surface area, mg m 2 suppressed bone turnover and protected against trabecular bone loss, cortical thinning and the reduction in vertebral and femoral bone strength in a dose dependent manner [Only registered and activated users can see links. Click Here To Register...] Additionally, new combinations and treatment sequencing strategies are also being assessed, often as a consequence of resistance identified in previous trials e