Preferred carbonyl molecules include, but are not limited to; aldehyde and ketone containing molecules that shift the allosteric equilibrium of hemoglobin to the high oxygen affinity state; small molecule immunomodulators that form Schiff base adducts with biological amines of the immune system including, but not limited to, Tucaresol, Isotucaresol and derivatives of Tucaresol and Isotucaresol; adjuvants that form Schiff base adducts with biological amines of the immune system including, but not limited to, saponin derivatives, natural and synthetic versions of QS 21, and synthetic versions of QS 21 that retain an aldehyde

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